ea0065oc1.1 | Metabolism and Obesity | SFEBES2019
Schiffer Lina
, Sinclair Alexandra J
, O'Reilly Michael W
, Westgate Connar
, Mashood Afeefa
, Palmer Elliot
, Gilligan Lorna C
, Singhal Rishi
, Taylor Angela E
, Dunn Warwick B
, Arlt Wiebke
, Storbeck Karl-Heinz
Polycystic ovary syndrome (PCOS) affects 10% of women and is associated with an increased risk of type 2 diabetes and fatty liver disease. Androgen excess is an important driver of metabolic risk in PCOS. In adipose tissue from women with PCOS, increased activation of androstenedione (A4) to testosterone (T) by the enzyme AKR1C3 results in systemic lipotoxicity. Recent in-vitro studies also demonstrated that T and 11-ketotestosterone (11KT) activate the androgen recep...